Leveraging Embryonic Zebrafish To Prioritize ToxCast Testing
نویسندگان
چکیده
منابع مشابه
Histopathological evaluation of zebrafish (Danio rerio) larvae following embryonic exposure to MgO nanoparticles
The aim of this study was to investigate the histopathological changes in zebrafish larvae following embryonic exposure to nanoparticles of magnesium oxide (MgONPs). The toxicity of metal oxide nanoparticles is attracting increasing attention. Among these nanomaterials, MgONPs are particularly interesting as a low cost and environmentally-friendly material. Histological investigations are used ...
متن کاملHistopathological evaluation of zebrafish (Danio rerio) larvae following embryonic exposure to MgO nanoparticles
The aim of this study was to investigate the histopathological changes in zebrafish larvae following embryonic exposure to nanoparticles of magnesium oxide (MgONPs). The toxicity of metal oxide nanoparticles is attracting increasing attention. Among these nanomaterials, MgONPs are particularly interesting as a low cost and environmentally-friendly material. Histological investigations are used ...
متن کاملThe ToxCast program for prioritizing toxicity testing of environmental chemicals.
The U.S. Environmental Protection Agency (EPA) is developing methods for utilizing computational chemistry, high-throughput screening (HTS), and various toxicogenomic technologies to predict potential for toxicity and prioritize limited testing resources toward chemicals that likely represent the greatest hazard to human health and the environment. This chemical prioritization research program,...
متن کاملYield of genetic screening in inherited cardiac channelopathies: how to prioritize access to genetic testing.
BACKGROUND Identification of mutations in cardiac ion channel genes concurs to the diagnosis of long-QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia. However, because availability of genetic screening is still limited and reimbursement policies are lacking, there is a need of evidence-based criteria to prioritize access to genetic testing for these disea...
متن کاملEmbryonic exposure to sodium arsenite perturbs vascular development in zebrafish.
Exposure to arsenic in its inorganic form, arsenite, causes adverse effects to many different organs and tissues. Here, we have investigated arsenite-induced adverse effects on vascular tissues in the model organism zebrafish, Danio rerio. Zebrafish embryos were exposed to arsenite at different exposure windows and the susceptibility to vascular tissue damage was recorded at 72hours post fertil...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Science & Technology Letters
سال: 2015
ISSN: 2328-8930,2328-8930
DOI: 10.1021/acs.estlett.5b00123